Advantages and Disadvantages of Chromium Complexes

Advantages and Disadvantages of Chromium Complexes Chromium is one of the transition metal in periodic table that is known for its ability in improving one’s health condition by preventing diseases and gives treatment. However in human body, only very small amounts of chromium are required and they are often regarded as the essential trace element in human body. Back in 1950s, the uses of chromium as nutritional and medical enhancement to glucose metabolism was started when brewer’s yeast was suggested to contain a glucose tolerance factor (GTF) that prevented diabetes in experimental animals. (Schwarz k, Mertz W, 1959). It was only then this factor finally taken into consideration to be a biologically active form of trivalent chromium that could substantially lower the plasma glucose levels in diabetic mice based on studied done by Tuman RW and Doisy RJ in 1977. According to Fernando Guerrero and Martha Rodriguez-Moran, 2005, trivalent chromium (Cr3+) is an essential trace element required for the maintenance of normal glucose and fat metabolism. Because chromium potentiates the action of insulin, it was named from its recognition in the late 1950s as the glucose tolerance factor term that emphasizes its importance in glucose metabolism. Chromium is present in many foods, especially in liver, Brewer’s yeast, American cheese, w heat germ, vegetables such as carrots, potatoes, broccoli, and spinach, and is also present in alfalfa, brown sugar, molasses, dried beans, nuts, seeds, mushrooms, and animal fats. An organically dynamic type of chromium takes part in glucose digestion system by improving the impacts of insulin. Insulin is produced by particular cells in the pancreas in light of increasing blood glucose levels, for example, after eating. Insulin binds to insulin receptors on the surface of cells, which actuates the receptors and invigorates glucose uptake by cells. Blood glucose levels are prevented from being elevated when insullin interact with insulin receptors whereby insulin will provides cells with glucose. Apart from affecting carbohydrate (glucose) metabolism, metabolism of fat and protein is also influnced by insulin. Impaired glucose tolerance or type 2 diabetes which is also known as non-insulin dependent diabetes mellitus may occur as the consequences of decrease response to insulin or decreased insulin sensitivity. Type 2 diabetes is characterized by elevated blood glucose levels and insulin resistance. The precise structure of the biologically active form of chromium is not known. Recent research suggests that a low-molecular-weight chromium-binding substance (LMWCr) may enhance the response of the insulin receptor to insulin. The following is a proposed model for the effect of chromium on insulin action. First, the inactive form of the insulin receptor is converted to the active form by binding insulin. The binding of insulin by the insulin receptor stimulates the movement of chromium into the cell and results in binding of chromium to apoLMWCr, a form of the LMWCr that lacks chromium. Once it binds chromium, the LMWCr binds to the insulin receptor and enhances its tyrosine kinase activity. The ability of the LMWCr to activate the insulin receptor is dependent on its chromium content. The LMWCr may be released from the cell in order to terminate its effects when insulin levels drop due to normalization of blood glucose levels. More recent studies have indicated that chromium enhances insulin action by increasing the insulin-stimulated translocation of glucose transporters to the cell membrane (Chen G, Liu P, Pattar GR, et al, 2006). Apart from type 2 diabetes, effects of chromium supplementation on gestational diabetes had also been examined. Gestational diabetes occurs in about 2% of pregnant women and usually appears in the second or third trimester of pregnancy. Adverse effects on the developing fetus must be prevent by tightly control the blood glucose levels in the body. Glucose tolerance usually turns back to normal after delivery. However, according to study, 30% to 40% of women who have had gestational diabetes develop type 2 diabetes within 5 to 10 years. An observational study in pregnant women did not find serum chromium levels to be associated with measures of glucose tolerance or insulin resistance in late pregnancy, although serum chromium levels may not reflect tissue chromium levels. Women with gestational diabetes whose diets were supplemented with 4 mcg of chromium per kilogram of body weight daily as chromium picolinate for eight weeks had decreased fasting blood glucose and insulin levels com pared with those who took a placebo. However, insulin therapy rather than chromium picolinate was required to normalize severely elevated blood glucose levels. Trivalent compounds (Cr III) do not cause any serious damage to body tissue, in fact, it is an important component of a balanced human and animal diet and its deficiency is detrimental to the glucose and lipid metabolism in mammals. The limitation of chromium in its application in human health is that it may cause different side effect to different person. The controversy surrounding chromium supplementation is due to the variability of the results gain from the evaluation of the effect of chromium in patients with diabetes and without diabetes. Some of them experienced positive improvement but some are only indicate little or no benefit at all. Most of the concerns regarding the long-term safety of chromium supplementation arise from several studies in cell culture, suggesting chromium (III), especially in the form of chromium picolinate, may increase DNA damage. Several studies have demonstrated the safety of daily doses of up to 1,000 mcg of chromium for several months. However, t here have been a few isolated reports of serious adverse reactions to chromium picolinate. Kidney failure was reported five months after a six-week course of 600 mcg of chromium/day in the form of chromium picolinate, while kidney failure and impaired liver function were reported after the use of 1,200-2,400 mcg/day of chromium in the form of chromium picolinate over a period of four to five months. Individuals with pre-existing kidney or liver disease may be at increased risk of adverse effects and should limit supplemental chromium intake. In addition, the use of the supplements of chromium over a prolonged period of time may result in a risk of chromium poisoning. This is due to chromium’s nuclear affinity, tending to result in its accumulation within cells. High doses of chromium which is about 600-2400 ÃŽ ¼g will makes rare side effects may occur such as damage to the liver, kidney, and bone marrow as well as rhabdomyolysis and psychiatric disturbances in some cases. The y have also been related to chromosomal damage and increased incidence of cervical arch defects as they are capable of cleaving DNA. Similar complex coumpound with Chromium Chromium vs vandium and zinc Apart of chromium, other transition metal that is found to have ability to be used as anti diabetic agent is vanadium and zinc. More than 2 8% of world’s population is suffering from diabetes (Wild et al., 2004). It is a condition in which body do not produce a hormone called insulin which is necessary for the absorption of glucose in cells (Rother, 2007). Scientists are looking for alternative approaches for the treatment of diabetes (Nahas et al., 2009). The glucose level in the blood plasma is controlled by uses of vanadium and zinc in form of inorganic salts. Research shows that undesireable side effets often associated with the elements that are poorly absorbed in their organic forms and required high doses. Research has been conducted to prove that vanadium complexes with organic ligands to be less toxic with improved solubility and lipophilicity. Thera are a few number of vanadium complex which posses the insulin-mimetic properties that have been produced. The molecular mechanism responsible for the insulin-like effects of vanadium compounds have been shown to involve the activation of several key components of insulin-signaling pathways. It is interesting that the vanadium effect on these signaling systems is independent of insulin receptor protein tyrosine kinase activity, but it is associated with enhanced tyrosine phosphorylation of insulin receptor substrate. Chromium supplementation significantly improved glycemia among patients with diabetes but do not show any significant effect on glucose metabolism in healthy individuals. Higher zinc intake has also been associated with a slightly lower risk of type 2 diabetes in women. Besides chromium and vanadium, there is also a strong connection between zinc and insulin. In fact, people with diabetes frequently have lower levels of zinc than those without diabetes. One reason for this is that diabetics tend to have increased excretion of zinc. Additionally, high blood sugar levels create significant oxidative stress. The use of antioxidants has been shown to help improve oxidation, while also enhancing the body’s response to insulin. Unfortunately, the risk of cardiovascular disease among diabetics is more difficult to address. Coronary heart disease is a major cause of death among people with type 2 diabetes. This, of course, is due in large part to obesity, but also to risk factors such as high blood pressure, high LDL cholesterol levels, and an imbalanced ratio of LDL to HDL cholesterol. Like chromium and vanadium, the body also can’t make zinc, so it must be taken from food sources. Zinc is stored in the muscles, blood cells, retina of the eye , skin, bone, kidney, liver, pancreas, and in men, prostate. Interestingly, zinc has long been an ingredient used in â€Å"older† insulins, such as Regular, NPH, and Lente. Zinc is also necessary for the formation of insulin in the pancreas’s beta cells. For these reasons, researchers have looked at the role of zinc supplementation in the prevention and treatment of Type 2 diabetes. Research shows that zinc, an essential trace element responsible for over 300 enzyme functions, can aid in normalizing the negative effects of diabetes mellitus. According to the study, zinc has been shown to mitigate the harmful effects of diabetes by improving glycemic control in type I and type II diabetes. Many of the enzyme systems in which zinc is a necessity for are involved with the metabolism of blood sugar, and therefore make zinc a natural catalyst for insulin secretion. The pancreas is an endocrine gland responsible for producing hormones like glucagon, somatostatin, and insulin. The beta cells that secrete insulin in the pancreas are also highly stored with zinc. The beta cells will suffer without the high concentrations of zinc. Fortunately, beta cells are equipped with their own special transporter called zinc transporter 8, which makes it easy for the beta cells to store the zinc. However, it is known that any metamorphosis of the genes in the zinc transporter 8 causes type 2 diabetes. It is also now known that antibodies against the zinc transporter are present in type 1 diabetic patients, which means that these antibodies are associated with type 1 diabetes. It is no wonder why zinc is as popular as it is for supplementation. In addition to mending the difficulties brought on by diabetes, zinc also serves to maintain a healthy immune system, controls hair loss, halts impotence, improves brain function, prevents loss of taste or smell, and much more. References Guerrero-Romero, F.; Rodrà ­guez-Morà ¡n, M. (2005). Complementary Therapies for Diabetes: The Case for Chromium, Magnesium, and Antioxidants. Archives of Medical Research 36 (3): 250–257 Massey, P. (2013). Diabetes and the Role of Dietary Supplements. Bioactive Food as Dietary Interventions for Diabetes. pp. 17–94. Schwarz K, Mertz W: Chromium (III) and the glucose tolerance factor. Arch Biochem Biophys 85: 292–295, 1959 Tuman RW, Doisy RJ: Metabolic effects of the glucose tolerance factor (GTF) in normal and genetically diabetic mice. Diabetes 26:820–826, 1977 Vincent JB. Elucidating a biological role for chromium at a molecular level. Acc Chem Res. 2000;33(7):503-510. Chen G, Liu P, Pattar GR, et al. Chromium activates glucose transporter 4 trafficking and enhances insulin-stimulated glucose transport in 3T3-L1 adipocytes via a cholesterol-dependent mechanism. Mol Endocrinol. 2006;20(4):857-870. Pattar GR, Tackett L, Liu P, Elmendorf JS. Chromium picolinate positively influences the glucose transporter system via affecting cholesterol homeostasis in adipocytes cultured under hyperglycemic diabetic conditions. Mutat Res. 2006;610(1-2):93-100 Wang H, Kruszewski A, Brautigan DL. Cellular chromium enhances activation of insulin receptor kinase. Biochemistry. 2005;44(22):8167-8175.

Ya kun

Ya Kun is an established and has renown reputation for its coffee and kaya toast. It has been around us since 1944 when it registered itself as Ya Kun Coffee Stall. It differentiated its food by manufacturing its very own kaya that is used at all of the Ya kun outlets. Yakun now has expanded to a total of 11 countries in Asia and Middle Eastern region. As mentioned above in the Porter five forces, Ya kun faces both direct and indirect competitors in the industry. The direct competitors are Toastbox and Killiney kopitiam. The indirect competitors are Starbucks and Macdonalds.Although the indirect competitors are not in the traditional coffee and toast industry, they still possess threats that affect Ya Kun Identify Product offering Scale of operation Local Regional Global Limited Wide Product offering Scale of operation Local Regional Global Limited Wide Toastbox Toastbox was established in 2005 and it aims to recreate the warm atmosphere of local Nanyang coffee shops from the 1960s. It has successfully expanded both locally and internationally to countries such as Malaysia, Thailand, Philippines, Hong Kong and China. Killiney KopitiamKilliney Kopitiam has a rich history, from being established in the 1950s as â€Å"Qiong Xin He† and later renamed as â€Å"Killiney Koptiam† in 1993. They have now expanded their operations to countries such as Malaysia, Indonesia, Australia and Hong Kong. The vision of the company is to share the â€Å"Kopitiam† tradition through generations by educating the young.? Evaluate (str & weakenesses) Brand| Strength| Weakness| Ya Kun| * Uses social media (eg. Facebook, website) * Maintain the traditional menu * Expanded regionally * Outlets can be easily found in more places * ?Nostalgic appeal keeps older generation feel attached * Infused traditions with vibrancy and style * Attempt to attract the younger crowd who fancy dining in a traditional setting | * Limited variety (Product list) * Slightly overprice| Toas t Box| * Uses social media (Facebook, website, twitter) * Wide variety of choice in menu * Locates its cafes in the heartlands as well as the central business district to cater to a wide array of its target market * Expanded regionally| * Menu not on website.Only signature dishes * Toast and menu not as traditional | Killiney Kopitiam| * Uses social media (Facebook, website) * Wide variety of choice in menu * Offers quality products and services at affordable prices * Preserve the coffee shop tradition * Expanded regionally| * Menu is not attractive enough * Lack of updates in Facebook| Is YA KUN always stronger- which areas is it stronger and which weaker (the vulnerable areas)?

Las atracciones más visitadas de Estados Unidos en 2019

Geography of Arizona & Facts About the 48th State

Population: 6,595,778 (2009 estimate)Capital: PhoenixBordering States: California, Nevada, Utah, Colorado, New MexicoLand Area: 113,998 square miles (295,254 sq km)Highest Point: Humphreys Peak at 12,637 feet (3,851 m)Lowest Point: Colorado River at 70 feet (22 m)Arizona is a state located in the southwestern United States. It became a part of the U.S. as the 48th state (the last of the contiguous states) to be admitted into the Union on February 14, 1912. Today Arizona is known for its varied landscape, national parks, desert climate and the Grand Canyon. Arizona has recently been in the news due to its stringent and controversial policies on illegal immigration. 10 Geographic Facts About Arizona The first Europeans to explore the Arizona region were the Spanish in 1539. In the 1690s and early 1700s, several Spanish missions were established in the state and Spain established Tubac in 1752 and Tucson in 1775 as presidios. In 1812, when Mexico achieved its independence from Spain, Arizona became a part of Alta California. However with the Mexican-American War in 1847, the area of present-day Arizona was given up and it eventually became a part of the Territory of New Mexico.In 1863, Arizona became territory after New Mexico seceded from the Union two years earlier. The new Arizona Territory consisted of the western part of New Mexico.Throughout the rest of the 1800s and into the 1900s, Arizona began to grow as people moved into the area, including Mormon settlers who founded the cities of Mesa, Snowflake, Heber and Stafford. In 1912, Arizona became the 48th state to enter the Union.Following its entry into the Union, Arizona continued to grow and cotton farming and copper mini ng became the states two largest industries. After World War II, the state grew even more with the development of air conditioning and tourism to the states national parks also increased. In addition, retirement communities began to develop and today, the state is one of the most popular for people of retirement age on the West Coast.Today, Arizona is one of the fastest growing states in the U.S. and the Phoenix area alone has over four million residents. The total population of Arizona is hard to determine however because of its large number of illegal immigrants. Some estimates claim that illegal immigrants make up 7.9% of the states population.Arizona is considered one of the Four Corner states and it is best known for its desert landscape and highly varied topography. High mountains and plateaus cover more than half of the state and the Grand Canyon, which was carved over millions of years by the Colorado River, is a popular tourist destinations.Like its topography, Arizona also has a varied climate, though much of the state is considered desert with mild winters and very hot summers. Phoenix for instance has an average July high of 106.6ËšF (49.4ËšC) and a January average low of 44.8ËšF (7.1ËšC). By contrast, Arizonas higher elevations often have milder summers and very cold winters. Flagstaff for example has a January average low of 15.3ËšF (-9.28ËšC) and a July average high of 97ËšF (36ËšC). Thunderstorms are also common throughout much of the state.Because of its desert landscape, Arizona mainly has vegetation that can be classified as xerophytes - these are plants like cactus that use little water. The mountain ranges however have forested areas and Arizona is home to the larges stand of Ponderosa pine trees in the world.In addition to the Grand Canyon and its desert landscape, Arizona is known as having one of the best preserved meteorite impact sites in the world. The Barringer Meteorite Crater is about 25 miles (40 km) west of Winsl ow, Az. and is almost one mile (1.6 km) wide and 570 feet (170 m) deep.Arizona is one state in the U.S. (along with Hawaii) that does not observe Daylight Saving Time.To learn more about Arizona, visit the states official website. SourceInfoplease.com. (n.d.). Arizona: History, Geography, Population and State Facts- Infoplease.com. Retrieved from: http://www.infoplease.com/ipa/A0108181.htmlWikipedia.com. (24 July 2010). Arizona - Wikipedia, the Free Encyclopedia. Retrieved from: http://en.wikipedia.org/wiki/Arizona